A recent study conducted by John Hopkins University in Baltimore revealed that carotid intima-media thickness (cIMT) in children with chronic kidney diseases (CKD) was significantly higher than those of healthy controls. The said measurements were made via ultrasound. The kidney ultrasound is one type of abdominal ultrasound imaging.
These findings were culled from data collected during the Chronic Kidney Disease in Children panel study. Dr. Tammy M. Brady and his colleagues went through 101 young participants whose ages ranged from two to eighteen years old. These children were all afflicted with CKDs, having a median Glomerular Filtration Rate (GFR) of 42.9 milliliters per minute per 1.73 m². 97 health controls were also involved in the study in a course of one year.
It was observed that those with CKD had a median cIMT of 0.43 mm while healthy controls had 0.41 mm. Even with multivariable adjustment, the former were still found with elevated cIMT. Moreover, elevations in mean cIMT were attributed to other conditions. Hypertension was associated with a 0.04 mm cIMT increase while dyslipidemia with 0.05 mm. Researchers employed 6 standardized B-mode ultrasound measurements to come up with the data.
Having analyzed their study results, the research team concluded that children with CKD have increased cIMT, with dyslipidemia and hypertension being prominent risk factors. Furthermore, they weren’t able to find a significant correlation between cIMT and other factors such as pubertal status, birth weight, BMI, GFR, gender, race, calcium, phosphorus, and CKD etiology.
The results of the research were published in September 13 in the Clinical Journal of the American Society of Nephrology.